.png)
Next-Gen Tumor Models
.png)
Patient Mimicking 3D Tumor Model Platforms For Research and Drug Development.

THE PROBLEM
Right now close to 95% of new cancer drugs fail during clinical trials. Drug development has also become slower and more expensive over time in a phenomenon known as Erooms Law, meaning fewer and fewer drugs are making it to market. One of the root causes of these problems is that the tools researchers use, such as 2D cell cultures and patient-derived xenografts, do not accurately depict human biology.
Applications
Model Biological Processes
Study important biological processes involved in cancer growth, metastasis and drug resistance. Such processes include:
Vascularization
Angiogenesis
Immune Modelling
Cell-Cell Interactions
Hypoxia

Test Anti-Cancer Therapeutics
Gain more information about anti-tumor efficacy by testing new and repurposed therapeutics on real tumors. Compatible test agents include:
Chemotherapies
Immunotherapies
Nanomedicines
Angiogenesis Inhibitors

Biochemistry
Tumor spheroids are suitable to a wide range of studies and assay types.
-
Next generation sequencing
-
CRISPR
-
Western Blot (protein extraction)
-
qPCR
-
Immunofluorescence
-
Metabolomics
-
Proteiomics
-
Genomics
-
Transcriptomics
-
Immunohistochemistry and H&E
-
Flow cytometry
.png)
Rewriting Erooms Law.
